Morphing peptide backbones into heterocycles
نویسندگان
چکیده
منابع مشابه
Morphing peptide backbones into heterocycles.
M icrobes employ several catalytic strategies to transform conformationally f lexible peptide chains into rigidified scaffolds that possess antibiotic or toxin activity. Prominent examples include the biosynthesis of the -lactam antibiotics of the penicillin and cephalosporin families (1) and the maturation of vancomycin (2) where distinct structural modifications to the nascent peptide chains ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0802300105